Familial Hemiplegic Migraine

Familial Hemiplegic Migraine (FHM) is a variation of Hemiplegic Migraine where at least one first-degree or second-dgree relative also has Hemiplegic Migraine.

Currently, there are three subtypes of FHM: FHM1-FM3. In FHM1 chromosome 19 has a mutation in the CACNA1A gene. In FHM2 chromosome 1 has a mutation on the ATP1A2 gene. In FM3 chromosome 2 has a mutation on SCN1A gene.

The Role of Genes and Accurate Assessment in the Hemiplegic Migraine Patient

For those of us already suffering from Hemiplegic Migraine (HM), we are already aware that HM is a rare form of migraine with aura that involves significant motor weakness. It can occur both in sporadic and familial disorder. Familial Hemiplegic Migraine (FHM) is a dominantly inherited migraine. By studying genetics, researchers have been able to identify certain mutated genes, or changes to how the genes are sequenced. Read More