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Familial Hemiplegic Migraine
Familial Hemiplegic Migraine (FHM) is a variation of Hemiplegic Migraine where at least one first-degree or second-dgree relative also has Hemiplegic Migraine.
Currently, there are three subtypes of FHM: FHM1-FM3. In FHM1 chromosome 19 has a mutation in the CACNA1A gene. In FHM2 chromosome 1 has a mutation on the ATP1A2 gene. In FM3 chromosome 2 has a mutation on SCN1A gene.
For those of us already suffering from Hemiplegic Migraine (HM), we are already aware that HM is a rare form of migraine with aura that involves significant motor weakness. It can occur both in sporadic and familial disorder. Familial Hemiplegic Migraine (FHM) is a dominantly inherited migraine. By studying genetics, researchers have been able to identify certain mutated genes, or changes to how the genes are sequenced.